Tirzepatide
Tirzepatide
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Tirzepatide
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Tirzepatide is a novel, synthetic, dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist under investigation for its potential in treating type 2 diabetes and obesity. By combining the actions of GIP and GLP-1, Tirzepatide aims to improve glycemic control and promote weight loss more effectively than existing monotherapies. This dual agonist approach enhances insulin secretion, suppresses glucagon levels, and slows gastric emptying, contributing to improved metabolic outcomes. Requires reconstitution before use.
Characteristics
|
Molecular Formula |
C225H348N60O68 |
|
CAS Number |
2023788-19-2 |
|
Molar Mass |
5047.61 g/mol |
|
Amino Acid Sequence |
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly |
|
Synonyms |
LY3298176 |
|
Solubility |
Water-soluble |
|
Organoleptic Profile |
White to off-white powder |
|
Composition |
Lyophilized powder - requires reconstitution |
How does Tirzepatide work?
Tirzepatide is a novel synthetic peptide that acts as a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Its unique structure allows it to activate both GIP and GLP-1 receptors, which are found in various tissues throughout the body.
Research
Glycemic Control
Multiple clinical trials have investigated Tirzepatide's effects on glycemic control in individuals with type 2 diabetes:
- Significant reductions in HbA1c levels compared to placebo and active comparators
- Improvements in fasting and postprandial glucose levels
Weight Management
Studies have examined Tirzepatide's impact on body weight:
- Substantial weight loss is observed in individuals with obesity or overweight
- Weight loss effects appear to be dose-dependent
Cardiovascular Effects
Research has explored potential cardiovascular impacts:
- Improvements in lipid profiles, including reductions in triglycerides and LDL cholesterol
- Modest reductions in blood pressure have been observed in some studies
Renal Function
Limited data suggest potential renal effects:
- Reductions in albuminuria reported in some trials
- Long-term effects on kidney function require further investigation
Side Effects
The most common side effects reported in clinical trials include:
- Gastrointestinal symptoms (nausea, vomiting, diarrhea)
- Injection site reactions (pain, redness, itching)
- Hypoglycemia (low blood sugar) when used with insulin or sulfonylureas
- Increased heart rate
- Allergic reactions (rare)
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