Thymosin Alpha-1
Thymosin Alpha-1
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Thymosin Alpha-1
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Thymosin Alpha-1 is a naturally occurring peptide derived from the thymus gland, noted for its immunomodulatory and cellular signaling properties. This 28-amino acid peptide is involved in cellular processes related to immune system functioning, including T-cell differentiation and cellular communication. Thymosin Alpha-1 has been extensively studied for its potential in laboratory research examining viral infections, cellular response, and immune modulation. Needs reconstitution before use.
Characteristics
|
Molecular Formula |
C129H215N33O55 |
|
CAS Number |
62304-98-7 |
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Molar Mass |
3108.32 g/mol |
|
Amino Acid Sequence |
Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH |
|
Synonyms |
Thymalfasin, Zadaxin, Thymosin α1 |
|
Solubility |
Water-soluble |
|
Organoleptic Profile |
White to off-white powder |
|
Composition |
Lyophilized powder - requires reconstitution |
How does Thymosin Alpha-1 work?
Thymosin Alpha-1 is a naturally occurring peptide with immunomodulatory properties. Its mechanisms of action include:
- Binding to specific receptors on immune cells, particularly T-cells and dendritic cells
- Triggering intracellular signaling cascades involved in cellular activation and differentiation
- Influencing the production of signaling molecules like interleukin-2 and interferon-gamma
- Interacting with natural killer cell activity, potentially affecting cytotoxicity
- Contributing to the maturation and function of dendritic cells
- Observed to interact with inflammatory pathways by affecting cytokine production
Research Applications
Research has investigated Thymosin Alpha-1 in various laboratory settings:
- Viral research: Studied for potential antiviral activity against hepatitis B and C, HIV, and influenza viruses
- Cellular response: Investigated as an adjuvant in laboratory studies examining cellular activity, potentially influencing the effectiveness of other compounds
- Immune modulation: Explored in laboratory models examining cellular response in conditions like rheumatoid arthritis and multiple sclerosis
- Immunological research: Examined in studies of primary and secondary immune cell function
- Tissue repair: Studied for the potential to influence wound repair processes in laboratory settings
Oberservations in Studies
In clinical studies, Thymosin Alpha-1 has generally been well-tolerated. Reported side effects include:
- Mild injection site reactions (most common)
- Rare instances of flu-like symptoms (fever, chills, fatigue)
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