Tesamorelin

Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analog that stimulates the production and release of endogenous growth hormone (GH) from the anterior pituitary gland. This peptide has been extensively researched for its potential to improve metabolic health, reduce visceral adipose tissue (VAT), and enhance cognitive function in various populations, including those with HIV-associated lipodystrophy and age-related cognitive decline. Requires reconstitution before use.

Characteristics

How does Tesamorelin work?

Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analog that has been the subject of extensive research in the field of endocrinology and metabolism. This peptide's primary mechanism of action involves binding to and activating the growth hormone-releasing hormone receptor (GHRHR) in the anterior pituitary gland. This activation stimulates the synthesis and pulsatile release of endogenous growth hormone (GH), which in turn promotes the production of insulin-like growth factor-1 (IGF-1) in the liver and other tissues.

• Visceral Adipose Tissue (VAT) Reduction: Clinical studies have shown that tesamorelin can significantly reduce VAT in individuals with HIV-associated lipodystrophy and obese individuals without HIV. This reduction in VAT has been associated with improvements in metabolic health markers.
• Insulin Sensitivity: Investigations have indicated that tesamorelin treatment may improve insulin sensitivity in certain populations, including individuals with HIV-associated lipodystrophy and obese individuals without HIV.
• Cognitive Function: Some studies have explored tesamorelin's potential effects on cognitive function in older adults with mild cognitive impairment (MCI). Preliminary findings suggest possible improvements in executive function, attention, and memory.
• Muscle Mass and Strength: Research has indicated that tesamorelin may increase muscle mass and strength in older adults and individuals with HIV-associated lipodystrophy.
• Bone Health: Studies have observed increases in bone mineral density (BMD) in individuals with HIV-associated lipodystrophy following tesamorelin treatment.

Side Effects

• Injection site reactions
• Edema
• Arthralgia
• Hypersensitivity reactions

Less frequent side effects may include headache, dizziness, and gastrointestinal disturbances. In rare cases, tesamorelin may cause carpal tunnel syndrome or increase the risk of malignancy.