CJC-1295 (no DAC)

CJC-1295 is a synthetic peptide that stimulates the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in mammals. This peptide is a modified version of growth hormone-releasing hormone (GHRH) with enhanced stability and bioavailability. CJC-1295 works by binding to GHRH receptors in the pituitary gland, leading to increased GH production and secretion. The peptide has been studied for its potential to improve body composition, increase bone density, and enhance immune function. Requires reconstitution before use.

Characteristics

How does CJC-1295 work?

CJC-1295 is structurally similar to endogenous GHRH but has been modified to increase its half-life and bioavailability. Research indicates that CJC-1295 binds to GHRH receptors on somatotroph cells in the anterior pituitary, activating the cAMP signaling pathway. This activation leads to increased transcription of the GH gene, resulting in enhanced synthesis and secretion of GH.

Research

• Growth Hormone and IGF-1 Levels: Multiple studies have demonstrated that CJC-1295 administration can significantly increase circulating levels of GH and insulin-like growth factor 1 (IGF-1) in animal models. Research in healthy adult males has shown that a single dose of CJC-1295 can lead to sustained elevations in GH and IGF-1 for several days.
• Body Composition: Research in animal models has suggested potential effects on body composition. Studies in rats have found that CJC-1295 administration was associated with increased lean body mass and decreased fat mass.
• Bone Density: Some animal studies have investigated the effects of CJC-1295 on bone metabolism. Research in aged rats has reported improvements in bone mineral density following CJC-1295 treatment.
• Immune Function: Limited research has explored the potential immunomodulatory effects of CJC-1295. Studies in mice have observed alterations in certain immune parameters following CJC-1295 administration, though more research is needed to fully understand these effects.

Side Effects

While the aforementioned studies did not report severe adverse effects, it's important to note that long-term safety data in is limited. Potential side effects associated with elevated GH levels may include fluid retention, joint discomfort, and alterations in glucose metabolism, though these have not been extensively studied in the context of CJC-1295 specifically.